Soyuz MS-22 carried Roscosmos cosmonauts Sergei Prokopeyev, Dmitry Petelin and NASA astronaut Frank Rubio to the International Space Station aboard the Soyuz spacecraft from the Baikonur Cosmodrome in Kazakhstan. The spacecraft suffered a thermal control system depressurization/leak on the ISS on December 15, 2022, possibly due to micrometeor impact. It will land back on Earth without crew and will be replaced by Soyuz MS-23.